This scientific poster explores advanced methods for assessing wound healing using long-term human skin culture models. By combining a novel wounding device with MedPharm’s Skin-Life Extension Preparation (SLEP) and high-throughput pharmacodynamic (HTPD) system, the study demonstrates improved consistency, extended culture duration, and more informative evaluation of inflammation, proliferation, and tissue remodeling in wound healing research.
Robustness of Ex Vivo, Human Skin as a Model of General Inflammation
This scientific poster explores ex vivo human skin as a model of general inflammation, highlighting its use for evaluating inflammatory responses across Th1, Th2, Th17, and LPS pathways. The data demonstrates how human skin models can support pathway differentiation, inhibitor assessment, and more predictive preclinical decision-making in inflammatory drug development.
Use of Reconstructed Tissue and 3D Printed CT-Based Nasal Casts for the Assessment of Nasal Delivery
This scientific poster explores advanced in vitro models for nasal drug delivery, including reconstructed nasal epithelium and CT-based 3D printed nasal casts (MedCast®). These approaches enable more predictive assessment of drug permeation, penetration, and regional distribution compared to traditional methods, supporting improved formulation selection and reducing risk in drug development.
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Technical Resources – Test 01
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MedPharm’s Center for Skin Biology: The Standard of Quality
MedPharm’s Center for Skin Biology (CSB) provides scientifically rigorous, end-to-end support for substantiating cosmetic and personal care claims. With over 25 years of skin biology expertise, proprietary human skin models, and integrated preclinical and clinical capabilities, CSB generates reliable, performance-based data to support product claims and differentiate brands in a competitive market.
Reducing API Concentration While Preserving Topical Drug Performance
This case study shows how MedPharm reduced API concentration in a topical formulation while maintaining drug performance. By optimizing excipient composition and improving thermodynamic activity, the team achieved equivalent skin permeation, reduced cost of goods, and supported successful clinical development and commercialization.
Blog: Unlocking the Potential of Nasal Drug Delivery: Strategies for Formulation Success
Technical Blog
Published: November 2025
Authors: Dr. Jon Lenn, Dr. Charles Evans, and Dr. Jon Volmer
Advancing Nasal Drug Delivery Through Formulation Strategy
Nasal drug delivery is an increasingly important route of administration for local and systemic therapies, including treatments for allergic rhinitis, migraines, vaccines, and central nervous system disorders. Compared with oral and injectable dosage forms, nasal delivery can offer rapid absorption, non-invasive administration, and improved patient adherence. However, the nasal cavity presents significant biological barriers that can limit drug residence time and absorption.
In this technical blog, MedPharm explores practical strategies for overcoming nasal delivery challenges, including formulation design considerations, device compatibility, and the use of advanced preclinical models to support successful development.
What’s Covered in This Technical Blog
- Why nasal drug delivery continues to gain momentum across multiple therapy areas
- Key anatomical and physiological barriers that impact nasal absorption
- Strategic considerations for solution versus suspension-based formulations
- The role of formulation characterization in improving residence time and performance
- How advanced nasal models can help de-risk development and accelerate timelines
📥 Access the Full Blog
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