This case study shows how MedPharm improved topical and transdermal drug delivery using its MedSpray® film-forming technology. By combining thermodynamically optimized formulations with an aerosol-based delivery system, MedSpray® enhanced drug permeation through the skin, increased tissue retention, and enabled both immediate and sustained release profiles. The result was improved formulation performance, better patient usability, and a differentiated topical drug delivery platform.

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This case study shows how MedPharm improved IVPT performance using MedFlux-HT®, an automated flow-through diffusion system. By maintaining optimal sink conditions and increasing sensitivity, MedFlux-HT® generated more reliable permeation data and enabled better formulation decisions.

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This case study shows how MedPharm optimized skin explant models to improve stability and extend tissue viability for inflammation and wound healing studies. By preserving physiological relevance and enabling multi-endpoint analysis, the model generated more predictive data and supported better development decisions.

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This case study shows how MedPharm developed a reconstructed nasal epithelium (RNE) model to improve prediction of nasal drug delivery performance. By replicating key physiological features and benchmarking against clinical data, the model generated more reliable, human-relevant data and supported better formulation decisions.

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This case study shows how MedPharm improved nasal drug delivery modeling using advanced in vitro systems, including reconstructed human nasal epithelium and CT-based nasal casts (MedCast®). These approaches generated more predictive data, improved in vitro to in vivo correlation, and supported better formulation and development decisions.

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This case study shows how MedPharm resolved scale-up stability challenges by identifying process-driven root causes and optimizing manufacturing parameters. Through targeted studies and process optimization, variability was reduced and a robust, reproducible scale-up strategy was established.

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This case study shows how MedPharm solved solubility challenges in a small molecule formulation. The team identified the root cause of drug precipitation and optimized excipient selection. Through targeted solubility studies and formulation design, stability improved and regulatory risk was reduced. The result was a robust, scalable formulation that enabled continued development.

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This case study demonstrates how MedPharm stabilized a biologic formulation for topical nail delivery by identifying root causes of instability and optimizing excipient selection. Through targeted degradation studies and formulation optimization, MedPharm improved stability, reduced development risk, and enabled progression to IND-enabling studies.

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This case study highlights how MedPharm expanded formulation space to strengthen intellectual property and increase commercial value for a topical drug product. By developing and evaluating multiple formulation types, including gels, creams, ointments, and foams, MedPharm enabled broader patent coverage while maintaining consistent product performance. The result was a more defensible IP strategy, reduced competitive risk, and enhanced long-term asset value.

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