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Formulations for the Eye

The eye presents multiple target sites and delivery routes, each with unique formulation challenges.

Topical drops, gels, and ointments for the cornea, conjunctiva, or anterior region

Ocular inserts and implants for sustained release

Topical gels, ointments, or creams for eyelid application

Intravitreal injections for posterior segment delivery

Periocular routes

During development, formulation considerations may include:

MedPharm develops formulations across all ocular delivery routes, each requiring a distinct formulation strategy. Pre-formulation studies guide excipient selection and dosage form design.

MedPharm provides full formulation characterization using rheometry, Raman spectroscopy, texture analysis, and bespoke models incorporating real human tissue.

Drug substance characteristics
pH, osmolarity, and microbial preservation
Solution versus suspension systems
In-situ gelation triggered by temperature or shear
Solubilizers, co-solvents, and suspension stabilizers
Stability in processing solvents for sustained-release systems
Encapsulation and particle engineering
Sterility approaches and impact on product quality
Adhesion and retention in the presence of tears and blinking
Device compatibility and effects on product microstructure

Delivery to the Eye

MedPharm offers multiple in vitro ocular models to evaluate penetration and permeation to the front of the eye.

Diagram of ocular drug delivery routes including topical, periocular, and intravitreal administration

IVPT Using Micro Vertical Diffusion Cells

  • Penetration and permeation to the front of the eye
  • Uses excised cornea or sclera
  • Animal or human cadaver tissue
  • Optional wash-off to mimic tear flow

Reconstructed Ocular Tissue

  • Penetration and permeation to the front of the eye
  • Reconstructed cornea from human corneal cells
  • Maintains tissue integrity and tight junctions
  • Optional wash-off to mimic tear flow
  • Irritation measurements

EYEVPT® – In Development

Tear production and blinking are essential for ocular health, but they also create significant challenges for drug retention and delivery.

MedPharm is developing EYEVPT®, a model that:

  • Uses a reconstructed human cornea
  • Pumps tears across the tissue surface
  • Incorporates sweeping motion to mimic blinking

This system enables more realistic assessment of formulation retention, clearance, and ocular exposure, and supports evaluation of delivery mechanisms to the back of the eye.
Please ask MedPharm scientists for additional details.

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