Revisiting the General Solubility Equation explores new approaches to improving the in-silico prediction of aqueous solubility, a critical property in pharmaceutical drug discovery and formulation development. The study evaluates the widely used General Solubility Equation (GSE) and demonstrates that incorporating Topological Polar Surface Area (TPSA) alongside traditional descriptors improves the accuracy of solubility predictions across diverse chemical compounds. The findings highlight the value of computational modeling for accelerating early-stage drug development, supporting virtual compound screening, and improving decision-making during pharmaceutical research and formulation design.
Polymeric gels for intravaginal drug delivery
Polymeric Gels for Intravaginal Drug Delivery reviews the formulation strategies, materials, and performance considerations that influence successful vaginal drug delivery. The publication explores how polymeric gel systems can improve drug retention, mucoadhesion, and controlled release while addressing the unique physiological barriers of the vaginal environment. It also examines advances in thermogelling and mucoadhesive formulations, applications in infectious disease, contraception, and women’s health, and the regulatory, safety, and quality considerations required for product development. This review provides valuable insights for scientists developing intravaginal drug products, topical formulations, and advanced drug delivery systems.
Formulation Risk: The Cost of Non-Optimized Vehicles
Formulation challenges are a major but often overlooked source of development delays, clinical setbacks, and increased costs. For complex delivery routes, formulation optimization is critical to product performance, manufacturability, and long-term commercial success.
In this blog, MedPharm explores the impact of formulation risk, common causes of formulation failure, and why a systematic, route-specific development strategy can help reduce risk throughout the product lifecycle.
Alternative Drug Delivery Routes: Opportunities, Challenges, and How to Overcome Them
This article explores the challenges and opportunities of nasal drug delivery, including formulation strategies, biological barriers, and targeting approaches for local and systemic therapies. It also highlights MedPharm’s expertise in preformulation, characterization, and advanced nasal models designed to support successful product development
Unlocking the Potential of Nasal Drug Delivery
This blog explores the challenges and opportunities of nasal drug delivery, including formulation strategies, biological barriers, and targeting approaches for local and systemic therapies. It also highlights MedPharm’s expertise in preformulation, characterization, and advanced nasal models designed to support successful product development
Cosmetic Testing
The global cosmetics market is growing rapidly, driven by consumer demand, social media influence, and interest in science-backed, personalized skincare. As scrutiny of product claims increases, advanced testing is becoming essential. This article highlights the evolving landscape of cosmetic testing and how MedPharm’s Center for Skin Biology supports robust, evidence-based claims.
Advancing Topical Formulations With Innovative Preclinical Models
The high attrition rate in drug development, driven by factors like poor efficacy, safety, and developability, requires a strategic, early-stage approach to minimize risk and cost. Success depends on a robust development strategy and comprehensive characterization aligned with quality standards.
Key Learning Objectives
- Define the principles of topical formulation development and its role in drug success.
- Evaluate the utility of preclinical models, including in silico, in vitro, and ex vivo models, for formulation optimization and candidate selection.
- Develop a robust and phase-appropriate development package that de-risks a program before clinical studies.
A successful formulation approach uses scientific principles and innovative preclinical models to identify candidates with poor developability early, support informed decision-making, and reduce downstream risk.
From Concept To Market: Scaling And Manufacturing Semi-Solid Topical Drugs
Developing a semi-solid topical drug product demands a deeper level of scientific and process understanding than traditional solid dosage forms. Every choice, from excipient interactions to the order of ingredient addition, shapes the product’s microstructure, physical stability, and patient experience. Because subtle processing shifts can alter drug release, texture, and long-term uniformity, early formulation decisions carry significant consequences across clinical, scale-up, and commercial phases.
A Quality by Design mindset is essential as teams navigate the challenges of scaling these systems. Equipment geometry, shear profiles, thermal control, and mixing efficiency rarely translate directly from bench to plant, creating risk for changes in emulsification, drug distribution, or air incorporation. A holistic, cross-functional approach that integrates formulation science with engineering, quality, and manufacturing readiness is critical for de-risking transitions and securing reliable production.
This session provides foundational insight into topical formulation development, key scale-up considerations, and practical strategies for maintaining Critical Quality Attributes across the product lifecycle.
Demonstrating Clinical Efficacy and Tolerability of MedSpray®
This case study shows how MedPharm demonstrated the clinical efficacy and tolerability of MedSpray® in a non-inferiority study against a marketed antifungal treatment. Building on strong preclinical performance, the optimized MedSpray® formulation delivered equivalent antifungal activity while improving tolerability and maintaining comparable recurrence rates. These results confirm that enhanced topical drug delivery can translate into meaningful clinical outcomes and support both regulatory and commercial success.
Improving Drug Delivery Performance vs Marketed Products with MedSpray®
This case study shows how MedPharm improved topical and transdermal drug delivery performance using MedSpray® film-forming technology. By optimizing formulation design and comparing performance against marketed patches, gels, and creams, MedSpray® demonstrated higher drug permeation, improved release profiles, and greater formulation flexibility.