Poster: Development of an early wound model in human ex vivo skin explant as a preclinical model of wound healing

Animal models have been widely used in the wound healing field and have provided invaluable insights into crucial pathways of wound repair processes. However, translation of drug candidates identified in animal models to human therapies has been problematic and there has been a considerable interest in developing alternative models that could be better suited to preclinical evaluation.

The aim of the present work was to develop a model based on the use of ex vivo human skin explants, which could be employed to explore wound treatments, and to obtain a better understanding of the healing cascade of keratinocyte differentiation, collagen and fibrin deposition, inflammatory inhibition and healing time.

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