Polymeric Gels for Intravaginal Drug Delivery reviews the formulation strategies, materials, and performance considerations that influence successful vaginal drug delivery. The publication explores how polymeric gel systems can improve drug retention, mucoadhesion, and controlled release while addressing the unique physiological barriers of the vaginal environment. It also examines advances in thermogelling and mucoadhesive formulations, applications in infectious disease, contraception, and women’s health, and the regulatory, safety, and quality considerations required for product development. This review provides valuable insights for scientists developing intravaginal drug products, topical formulations, and advanced drug delivery systems.