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Gastrointestinal Delivery

Advancing Formulations for Localized and Systemic GI Therapies

At MedPharm, we specialize in the development of innovative drug products targeting the gastrointestinal (GI) tract, with expertise spanning topical GI treatments to systemic therapies delivered via mucosal absorption. Whether you are formulating for localized conditions or systemic bioavailability through oral mucosal, esophageal, or rectal delivery, our team applies a science-driven approach to maximize therapeutic outcomes.

We understand the unique challenges of delivering drugs to the GI tract—such as variable pH, enzymatic degradation, mucosal barriers, and transit times—and we design our formulations to overcome these complexities with precision and performance.

Gastrointestinal Delivery

Our Gastrointestinal Delivery Capabilities Include:

Mucosal Absorption Strategies

  • Buccal, esophageal, rectal, and intestinal formulations for local and systemic action
  • Expertise in permeation enhancers and bioadhesive technologies
  • Development of gels, suppositories, and liquid formulations optimized for retention and absorption

 

Stability and Release Optimization

  • Protection of sensitive APIs from enzymatic or acidic degradation
  • Targeted-release profiles to ensure drug delivery at the optimal site within the GI tract
  • Formulation technologies such as mucoadhesive systems and enteric coatings

 

Disease-Specific Focus

  • Formulations for inflammatory conditions (e.g., Crohn’s disease, ulcerative colitis)
  • Treatments for infections, motility disorders, and local GI cancers
  • GI mucosal barrier repair and regenerative medicine approaches

 

Customized Testing Models

  • In vitro and ex vivo models replicating human GI tissue environments
  • Permeation and irritation testing under simulated GI conditions
  • Bioavailability and pharmacokinetic assessments tailored to GI drug delivery

 

Why Choose MedPharm for Gastrointestinal Drug Development?

  • Deep expertise in overcoming GI-specific formulation challenges
  • Proven experience with mucosal absorption and site-specific targeting
  • Integrated development services from pre-formulation through clinical supply
  • Regulatory support for IND, NDA, and global market submissions

 

 


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