Accelerating Drug Development with Advanced Permeation Screening

At MedPharm, we recognize that making early formulation decisions is crucial for successful drug development. Our High-Throughput Skin Permeation Testing platform enables the rapid screening of multiple formulations, helping developers quickly and efficiently identify the most promising candidates. By streamlining permeation assessments early in the development process, we reduce time, cost, and risk, ensuring that only the best-performing formulations progress to later stages.

Why Choose High-Throughput Skin Permeation Testing?

• Rapid Formulation Screening – Quickly evaluates drug penetration profiles across various formulations.
• Data-Driven Decision Making – Provides early insights into API solubility, permeation rates, and enhancer efficacy.
• Optimized for Efficiency – Increases study throughput, shortening development timelines.
• Reduces Costs and Risk – Identifies lead formulations early, minimizing the need for late-stage reformulation.
• Regulatory-Ready – Complies with ICH, FDA, and EMA submission requirements.

How It Works

Our high-throughput testing employs automated Franz Diffusion Cells and customized permeation models to assess drug transport through ex vivo human skin and synthetic membranes.

1. Parallel Screening – Tests multiple formulations simultaneously for comparative analysis.
2. Automated Sampling and Quantification – Utilizes advanced analytical techniques (LC-MS, HPLC, UV-Vis) for real-time data collection.
3. Data Interpretation – Generates permeability coefficients, steady-state flux, and penetration profiles to rank formulations.
4. Lead Candidate Selection – Identifies optimal formulations for further in vitro permeation testing (IVPT) and clinical studies.

MedPharm’s High-Throughput Capabilities

• Rapid, Parallel Testing – Simultaneous testing of multiple formulations using automated Franz diffusion cells.
• Regulatory-Compliant Protocols – Developed in alignment with FDA, EMA, and ICH guidelines.
• Customizable Screening Models – Supports dermal, mucosal, ophthalmic, and transdermal drug delivery systems.
• Automated Sampling and Analysis – Ensures high-resolution, low-variability data collection with HPLC, LC-MS, and UV-Vis detection.

Key Applications

• Early-Stage Formulation Development – Rapidly compares API solubility, excipient compatibility, and penetration enhancers.
• Penetration Enhancer Studies – Evaluates the effects of chemical and physical penetration enhancers on drug delivery.
• Bioequivalence and Generic Drug Development – Aids ANDA submissions by demonstrating comparable permeation profiles.
• Vehicle Selection and Optimization – Identifies optimal formulation compositions for enhanced API delivery.
• Regulatory and Compliance Testing – Provides data-rich reports to support global regulatory filings.

Accelerate Your Formulation Development with MedPharm

MedPharm’s high-throughput screening approach ensures that only the best formulations advance to later development phases. By combining scientific expertise, advanced automation, and regulatory alignment, we help our clients reduce risk, optimize formulations, and accelerate their time to market.