Technical Blog
Published: November 2025
Authors: Dr. Jon Lenn, Dr. Charles Evans, and Dr. Jon Volmer

Advancing Nasal Drug Delivery Through Formulation Strategy

Nasal drug delivery is an increasingly important route of administration for local and systemic therapies, including treatments for allergic rhinitis, migraines, vaccines, and central nervous system disorders. Compared with oral and injectable dosage forms, nasal delivery can offer rapid absorption, non-invasive administration, and improved patient adherence. However, the nasal cavity presents significant biological barriers that can limit drug residence time and absorption.

In this technical blog, MedPharm explores practical strategies for overcoming nasal delivery challenges, including formulation design considerations, device compatibility, and the use of advanced preclinical models to support successful development.

What’s Covered in This Technical Blog

• Why nasal drug delivery continues to gain momentum across multiple therapy areas
• Key anatomical and physiological barriers that impact nasal absorption
• Strategic considerations for solution versus suspension-based formulations
• The role of formulation characterization in improving residence time and performance
• How advanced nasal models can help de-risk development and accelerate timelines

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