Nasal Drug Delivery: Opportunities, Challenges, and Formulation Strategies

Technical Article
Published: September 2025
Authors: Dr. Jon Lenn, Dr. Charles Evans, Dr. Jon Volmer

Advancing Alternative Drug Delivery Through Scientific Expertise

Nasal drug delivery is an increasingly important route of administration for local, systemic, and central nervous system therapies. Compared with oral and injectable dosage forms, nasal formulations can enable rapid onset of action, reduce systemic exposure, and improve patient adherence. However, biological barriers, rapid clearance mechanisms, and device-dependent delivery introduce formulation challenges that require specialized expertise.

In this technical article, MedPharm examines key considerations for nasal drug delivery within the broader context of alternative topical and transepithelial routes of administration. The article highlights route-specific challenges, formulation and device strategies, and the role of preclinical models in de-risking development and accelerating timelines.

What’s Covered in This Technical Article

• Core principles of nasal drug delivery and biological barriers
• Common formulation challenges and development considerations
• Strategies to optimize residence time, absorption, and targeting
• The impact of formulation–device interactions on delivery performance
• How preclinical nasal models support formulation selection and reduce risk

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