In a recent Analytical Special Feature with Drug Development & Delivery, industry experts weigh in about the the impacts of AI and automation in analytical labs.
New research challenges current theories on skin penetration of large molecular weight drugs offering hope for the discovery of new treatments of difficult-to-treat dermatological diseases. It is generally agreed that drugs with molecular weights above 1000 Daltons did not penetrate the skin at therapeutic levels and so weren’t applied topically for the treatment of dermatological diseases. However, researchers from GSK […]
Reckitt Benckiser scientists came to MedPharm with a challenge: can we devise models to determine how well their flurbiprofen throat spray and lozenge permeate the drug in the human pharynx? In response, the MedPharm team developed clinically relevant in vitro models and incorporated them into a study to test the permeation of each flurbiprofen formulation. Our product development team used ex vivo pharynx tissue from pigs and the team used ex vivo pharynx tissue from human […]
Sandoz produce a 5% Tavaborole topical solution to treat onychomycosis (T. rubrum), which is a fungus that infects nails. T. rubrum discolors nails it has infected and can make them painful to touch or cut. This topical solution provides an important alternative for patients where oral antifungal medications may have unwelcome side effects. Sandoz wanted to understand the impact of nail […]
A specialty pharmaceutical company requested MedPharm scientists to investigate a 5% cream formulation of a proprietary drug to see if the relatively high loading of the drug could be reduced. The aim was to achieve this without significantly changing the formulation’s excipients. The MedPharm team went back to first principles and measured the solubility and […]
MedPharm’s specialist tissue biologists have developed a range of in vitro activity models for measuring the pharmacokinetics and pharmacodynamics of topical products applied to the skin and other human epithelial tissues. These models don’t only measure the penetration and permeation of the active through the skin but also demonstrate that the active ingredient is positively impacting relevant […]
Pfizer’s Crisaborole ointment, 2% (Eucrisa) for atopic dermatitis is commonly applied by patients in combination with emollients. MedPharm designed and performed a study to determine the potential effect of emollient application on Eucrisa performance. MedPharm used its proprietary MedFlux-HT® automated flow system to determine the penetration of Eucrisa through fresh human skin in the presence and absence of these emollients. MedFlux-HT closely replicated a clinical environment for the study, preventing any drug […]
