Case Studies
Demonstrating the Skin Penetration Potential of a Large Aptamer
Challenging Skin Penetration Assumptions with GSK and the University of Reading New research is redefining assumptions about the skin penetration potential of large molecular weight drugs, offering hope for new therapies in difficult-to-treat dermatological diseases. It has long been believed that molecules above 1,000 Daltons cannot penetrate the skin at therapeutic levels, limiting their use […]
Proving Pharynx Formulation Equivalence with Specific Models
Reckitt Benckiser scientists came to MedPharm with a challenge: could we devise models to determine how well their flurbiprofen throat spray and lozenge deliver the drug into human pharynx tissue? In response, MedPharm’s team developed clinically relevant in vitro models and incorporated them into a comparative study evaluating the permeation of each flurbiprofen formulation. The […]
Cost-Effective Process Development Delivers Critical Clinical Trial Supply
MedPharm was asked to provide multiple 25 kg batches of a complex cream for a Phase 2 atopic dermatitis clinical trial on behalf of a global pharmaceutical company. A failure to supply or delay would have carried significant financial consequences for the project. The client specifically valued MedPharm’s detailed understanding of the product’s multi-stage manufacturing […]
Roundtable: Increasing the Robustness of IVPT Experiments
In a recent Analytical Special Feature with Drug Development & Delivery, industry experts weigh in about the the impacts of AI and automation in analytical labs.
Cost-effective process development of complex cream ensures consistent quality and on-time delivery of clinical trial material
MedPharm was asked to provide multiple 25 kg batches of a complex cream for an important Phase 2 atopic dermatitis clinical trial by a large global pharmaceutical company. Failure to supply or delay would have had major financial consequences for the project. Due to the nature of the request, the client valued MedPharm’s detailed understanding of […]
Teaming up with GSK and the University of Reading to demonstrate the skin penetration potential of a large aptamer
New research challenges current theories on skin penetration of large molecular weight drugs offering hope for the discovery of new treatments of difficult-to-treat dermatological diseases. It is generally agreed that drugs with molecular weights above 1000 Daltons did not penetrate the skin at therapeutic levels and so weren’t applied topically for the treatment of dermatological diseases. However, researchers from GSK […]
Proving pharynx formulation equivalence with specific models
Reckitt Benckiser scientists came to MedPharm with a challenge: can we devise models to determine how well their flurbiprofen throat spray and lozenge permeate the drug in the human pharynx? In response, the MedPharm team developed clinically relevant in vitro models and incorporated them into a study to test the permeation of each flurbiprofen formulation. Our product development team used ex vivo pharynx tissue from pigs and the team used ex vivo pharynx tissue from human […]
MedPharm’s TurChub model helps Sandoz expand marketing claims for nail fungal treatment
Sandoz produce a 5% Tavaborole topical solution to treat onychomycosis (T. rubrum), which is a fungus that infects nails. T. rubrum discolors nails it has infected and can make them painful to touch or cut. This topical solution provides an important alternative for patients where oral antifungal medications may have unwelcome side effects. Sandoz wanted to understand the impact of nail […]
Formulation optimization of topical treatment led to same efficacy with 30% less of the active pharmaceutical ingredient
A specialty pharmaceutical company requested MedPharm scientists to investigate a 5% cream formulation of a proprietary drug to see if the relatively high loading of the drug could be reduced. The aim was to achieve this without significantly changing the formulation’s excipients. The MedPharm team went back to first principles and measured the solubility and […]
Demonstrating application of in vitro disease activity model to clinical situation
MedPharm’s specialist tissue biologists have developed a range of in vitro activity models for measuring the pharmacokinetics and pharmacodynamics of topical products applied to the skin and other human epithelial tissues. These models don’t only measure the penetration and permeation of the active through the skin but also demonstrate that the active ingredient is positively impacting relevant […]
