Advancing Formulations for Localized and Systemic GI Therapies

At MedPharm, we specialize in the development of innovative drug products targeting the gastrointestinal (GI) tract, with expertise spanning topical GI treatments to systemic therapies delivered via mucosal absorption. Whether you are formulating for localized conditions or systemic bioavailability through oral mucosal, esophageal, or rectal delivery, our team applies a science-driven approach to maximize therapeutic outcomes.

We understand the unique challenges of delivering drugs to the GI tract—such as variable pH, enzymatic degradation, mucosal barriers, and transit times—and we design our formulations to overcome these complexities with precision and performance.

Precision Formulation for Women’s Health

MedPharm’s expertise in vaginal drug delivery supports the development of safe, effective, and patient-centric therapies that meet the unique physiological and regulatory requirements of mucosal administration. Whether you’re developing treatments for infectious diseases, hormonal imbalance, contraception, or systemic delivery via the vaginal route, MedPharm delivers proven strategies that move your product forward with confidence.

Why Vaginal Delivery?

The vaginal route offers direct access to local tissue, a large surface area for absorption, and the potential to bypass first-pass metabolism—making it an ideal pathway for both local and systemic therapeutic delivery. However, formulating for this route requires deep understanding of:

• Vaginal pH variability

• Mucosal permeability and retention

• Patient comfort and compliance

• Microbiota sensitivity

• Regulatory and device compatibility considerations

MedPharm brings this specialized knowledge to every vaginal drug development program we support.

Formulation Capabilities

Our team develops and optimizes a wide range of vaginal dosage forms, including:

• Gels and creams for localized or systemic absorption

• Vaginal rings with sustained-release properties

• Suppositories and ovules for targeted delivery

• Foams and films for ease of use and rapid distribution

• Mucoadhesive formulations to enhance retention and effectiveness

Each formulation is carefully tailored to address your molecule’s characteristics, therapeutic goals, and patient population.

Analytical and Preclinical Support

To accelerate your development program and meet regulatory expectations, MedPharm provides:

• In vitro release and permeation testing using vaginal tissue models

• Compatibility testing with common applicators and devices

• Microbial limit and stability testing under ICH conditions

• Mucoadhesion and rheology profiling to assess product performance

• Histological and morphological assessments of tissue integrity

Clinical and Regulatory Readiness

MedPharm’s integrated approach supports a seamless transition from lab to clinic. We ensure your vaginal drug product meets global regulatory expectations with:

• Customized CMC packages for IND, NDA, and 505(b)(2) submissions

• Clinical trial material (CTM) manufacturing in scalable formats

• QP-reviewed documentation for European submissions

• Strategy alignment for labeling, shelf life, and packaging

A Trusted Partner in Women’s Health Innovation

With decades of experience in mucosal delivery and topical formulation science, MedPharm is uniquely positioned to help clients develop differentiated vaginal therapies that are safe, effective, and commercially viable. Whether you are entering preclinical development or preparing for late-stage clinical trials, our team provides the scientific rigor and regulatory insight your program demands.

Optimized Formulations for Nail and Hard Tissue Penetration

At MedPharm, we specialize in ungual drug delivery, focusing on the development of advanced topical formulations designed to penetrate the hard keratin structure of nails. Our solutions are effective for treating onychomycosis, nail psoriasis, and various other nail-related conditions. Our scientifically-driven formulation strategies, penetration enhancement technologies, and in-vitro testing expertise ensure that ungual drug products achieve optimal bioavailability, sustained retention, and enhanced therapeutic efficacy.

With customized excipients, controlled-release mechanisms, and permeability optimization, MedPharm’s ungual drug delivery solutions provide targeted treatment, leading to improved patient compliance and success in meeting regulatory requirements.

Optimized Formulations for Targeted Ear Therapies

At MedPharm, we specialize in otic drug delivery, developing advanced formulations designed for precise, effective, and patient-friendly treatments of ear infections, inflammation, and other auditory conditions. Our expertise in liquid, suspension, and semi-solid otic formulations, combined with cutting-edge permeation enhancement technologies and regulatory-compliant manufacturing, ensures that otic drugs achieve optimal absorption, retention, and therapeutic performance.

With customized viscosity, pH-balanced formulations, and preservative-free options, MedPharm’s otic drug delivery solutions provide enhanced bioavailability, prolonged drug retention, and improved patient compliance.

Optimized Formulations for Targeted Absorption

At MedPharm, we specialize in mucosal drug delivery by developing advanced formulations for buccal, nasal, vaginal, and rectal applications. With industry-leading formulation expertise, in vitro testing capabilities, and GMP-compliant manufacturing, we ensure targeted absorption, enhanced bioavailability, and patient-friendly administration.

Our approach integrates mucoadhesive technologies, permeation enhancers, and controlled-release strategies to optimize drug delivery while prioritizing patient safety and regulatory compliance.

Precision Formulations for Enhanced Ocular Therapeutics 

At MedPharm, our expertise in ophthalmic drug delivery ensures that both topical and transdermal ocular formulations are designed for optimal corneal penetration, sustained drug release, and patient compliance. We specialize in creating sterile, bioavailable, and effective ophthalmic formulations, utilizing advanced drug delivery technologies to maximize therapeutic impact while minimizing systemic exposure.

With a profound understanding of ocular physiology, permeability challenges, and regulatory compliance, we assist pharmaceutical companies in developing ophthalmic solutions tailored for both anterior and posterior eye conditions, ensuring safety, efficacy, and commercial readiness.

Optimized Inhalation and Nasal Formulations for Effective Pulmonary Absorption 

At MedPharm, we specialize in respiratory drug delivery, developing advanced inhalable and nasal formulations designed for precise, efficient, and patient-friendly administration. Our expertise includes liquid sprays, dry powder inhalers (DPIs), and nebulized formulations. We ensure that respiratory drugs achieve optimal lung deposition, rapid onset, and enhanced bioavailability while maintaining regulatory compliance and stability.

Our scientifically driven approach, combined with in-vitro bioequivalence testing, particle size optimization, and GMP-compliant manufacturing, enables the development of high-performance respiratory therapies for conditions such as asthma, COPD, allergic rhinitis, and nasal infections.

Targeted Topical & Transdermal Solutions for Enhanced Therapeutic Outcomes 

 

At MedPharm, we specialize in dermal drug delivery, developing topical and transdermal formulations that offer localized or systemic therapeutic effects. With our cutting-edge formulation expertise, in-vitro testing capabilities, and GMP-compliant manufacturing processes, we ensure that our dermal drug products achieve optimized absorption, bioavailability, and patient compliance.

Whether creating creams, gels, lotions, or ointments, MedPharm’s scientifically driven approach guarantees consistent product performance, enhanced stability, and regulatory compliance from early-stage development through to commercial production.